Light Sheet Fluorescence Microscopy
Light Sheet Microscopes for Biological Imaging
PhaseView develops light sheet microscopy systems for three-dimensional imaging of biological specimens. Our instruments are designed for a broad range of applications, from live model organisms and small samples to cleared tissues, whole organs, and large specimens.
This website provides information about the Alpha3 microscope series, the technologies used in our imaging systems, and their applications in life science research. You can explore different microscope configurations, imaging capabilities, sample mounting solutions, and options for working across multiple scales and magnifications.
We also describe the principles behind our approach to light sheet fluorescence microscopy, including optical sectioning, illumination homogeneity, image acquisition, and the reduction of photodamage. Application examples illustrate how these technologies can be used for high-resolution 3D imaging of both live and cleared samples.
The Resources section contains technical materials, documentation, and additional information for researchers, imaging facilities, and laboratories considering light sheet microscopy for their work.
Alpha3 and Alpha3 Facility Edition
Alpha3 and Alpha3 Facility Edition are PhaseView’s established light-sheet imaging platforms, designed for laboratories and imaging facilities requiring broad optical, mechanical and application flexibility. Built around adaptable configurations, these systems support a wide range of samples, objectives, illumination wavelengths and imaging workflows. Their modular architecture allows each platform to be configured around the experiment, while direct PhaseView support covers application planning, installation, training and ongoing operation.
Introducing AlphaX
AlphaX is PhaseView’s new light-sheet imaging platform, combining redesigned ergonomics, new software and the xSPIM environment for a more intuitive and efficient imaging workflow.
From whole-sample exploration and region selection to acquisition and review, AlphaX brings the complete imaging process into a unified environment.
More details and technical specifications are coming soon.
PhaseView at Upcoming Conferences & Exhibitions
Neuroscience 2026
November 14–18, 2026
Walter E. Washington Convention Center, Washington, D.C.
Cell Bio 2026
December 12–15, 2026
San Diego Convention Center, San Diego, CA
Focus on Microscopy 2027
March 21–24, 2027
Osaka International Convention Center, Osaka, Japan
ELMI 2027
June 22–25, 2027
Magazzini del Cotone Congress Centre, Genoa, Italy
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